Sunday, April 10, 2016

More than Meets the Eye (JOURNYS Original Research Article on Sleep Published in Volume 7, Issue 1)

More Than Meets the Eye

Sleep is a mysterious and bizarre concept that has puzzled many people for centuries. Why do our bodies spend so much time inefficiently when we sleep? Yes, we need sleep to function, but what are our bodies really doing? Does our body just replenish energy during the precious time we spend asleep?

During one night, our bodies transition through four stages and two types of sleep. The four stages occur in cycles and the two types of sleep are NREM (non-rapid eye movement) sleep and REM (rapid eye movement) sleep. As we fall into unconsciousness, our bodies begin the sleep cycle with Stage 1. Stage 1 normally lasts five to ten minutes and is the transition between consciousness and sleep. It is also the stage where one may experience hallucinations, the feeling of falling, or floating weightlessly. The brain will begin to produce sleep spindles during Stage 2, which are rapid, rhythmic brain waves.1 Stage 2 lasts for about 20 minutes, during which body temperature decreases and heart rate begins to slow. Following Stage 2 is delta sleep, or Stage 3. Here the brain starts to produce deep, slow brain waves called delta waves – hence the name of Stage 3. As Stage 1 was the transitional period between consciousness and sleep, Stage 3 is the transitional period between light sleep and deep sleep. Up until the end of Stage 3, our bodies have been in NREM sleep. As Stage 3 concludes, the body begins to enter REM sleep.2 REM sleep characteristics can include the fluttering of eyes under the eyelids, irregular and shallow breathing, and loss of muscle control. REM sleep occurs about an hour after one first falls asleep and is also called Stage 4. The body is still and relaxed, save for a few occasional twitches, and blood pressure rises. This is also the stage in which dreaming will occur.3

The structure of sleep follows a pattern alternating between NREM sleep and REM sleep. The body usually goes through Stage 1 once throughout the night, passing through Stages 2 and 3 and finally entering REM sleep. After about 10 minutes of REM sleep, the body will return to Stage 2 and repeat this cycle throughout the night. The first time your body enters REM sleep, the stage will only last about ten minutes but by the end of the night, the last cycle of REM sleep can be up to 60 minutes long. For every cycle of sleep the body experiences, the length of REM sleep will increase while the length of delta sleep will decrease. By the end of the night, there is almost no delta sleep left in the cycle. Each cycle takes approximately 90 minutes and the body will go through the cycle of stages four to five times a night. When you awaken naturally, you will have just finished a period of REM sleep.1

Sleep is vital to human health. When our bodies fall into unconsciousness, they do a lot more than what it looks like they’re doing. Although it doesn’t seem like it, the amount of energy consumed by the brain does not decrease when the body enters sleep, primarily because of several systems in the brain active during sleep.

The first is a system that flushes waste from the brain. During consciousness, by-products of neural activity build up and every night sleep clears this build up. Since the brain is enclosed by a set of molecular gateways – the blood-brain barrier – the system that clears waste in the body does not extend to the brain. During sleep, cerebral spinal fluid (CSF) is pumped through the brain’s tissue and the waste is then flushed back into the circulatory system where it eventually works its way to the liver. As this system cleans the brain, brain cells shrink to allow CSF to flow more smoothly through tissue. This system is called the glymphatic system and is ten times more active during sleep versus consciousness.4

Another active region of the brain during sleep is waves produced during different stages of sleep. These different waves are characterized by frequencies corresponding to the nature of the stage it is released in. These waves show the amount of activity in the brain and our level of consciousness.

In Stage 1 and REM sleep, the brain produces theta waves which are usually measured at 4 to 7.5 cycles per second, or 4 to 7.5 hertz. These waves are also experienced during deep meditation. Theta state heightens receptivity and can be produced fleeting as the body wakes or falls asleep. In addition, during REM sleep, the brainstem blocks information from leaving the brain’s motor cortex so your muscles are relaxed and unmoving.5 Throughout Stage 2, sleep spindles will occur periodically as they are rhythmic waves and unvarying in form. The sleep spindles are measured between 10 and 14 hertz.6 In Stage 3, delta waves are produced. Their frequency ranges from 0 hertz to 4 hertz and they are the lowest set of frequencies a human brain will experience. Certain frequencies of delta waves trigger the release of growth hormone and are essential to the restorative process of sleep.5 These active portions of the brain during sleep contribute to the remedial nature of sleep. This means that our time sleeping is absolutely critical to our performance; the human body is actively working and cleansing itself when we are not aware.

              Throughout a night of sleep, dreams are perhaps the most least understood stage of unconsciousness. What are their purposes and what do they mean? Although there are no solid facts on the purposes of dreams, there are many theories as to why dreaming occurs.

              Dr. J. Allan Hobson, a psychiatrist and sleep researcher, believes that since we always wake after a period of REM sleep, dreaming is a way for the brain to “warm-up”. In dreams we anticipate the emotions, sights and sounds we’ll experience upon waking up. In this sense, dreams prepare our bodies to return to consciousness.7

              Another theory comes from Carl Jung, who believed that dreams are meant to recompense for the parts of our personality that are less developed when we are awake. However, a contradicting theory is claimed by Calvin Hall, who studied 2 week journals from test subjects. Hall states that dreams are continuous with ideas and behavior when we are awake.8 Even still, there are more opinions and arguments over what dreams are meant to do. A Nobel laureate named Francis Crick believed dreams were a way for the brain to discard bits and pieces of memories that were deemed irrelevant. Crick theorized that dreams were the accumulation of excess thoughts and ideas that didn’t make it into the brain’s memory.9 Thus, the reason why we hardly ever remember our dreams.

              To this day, scientists and experts still debate over the meaning of dreams, but across the controversy, all sides of the debate can agree that everyone has dreams – although most people forget them by the end of the night.

              At a glance, the mechanics of sleep seem simple: four stages of sleep and dreaming in between. However, with a closer look sleep is intricately complex and much more than meets the eye. This time that we spend asleep is not just our body lying around doing nothing - our bodies use the same amount of energy during asleep as consciousness, and sleep is just as complicated as being awake. Even today, extensive knowledge on sleep is not known, but every day experts learn more and more.




Bibliography

1. Russo, Michael. "Sleep: Understanding the Basics Causes, Symptoms, Treatment - Stages of Sleep." EMedicineHealth. Web. 14 Jan. 2015. 

2.  "What Happens When You Sleep?" National Sleep Foundation. Web. 8 Dec. 2014.   

3. Dement, W., and N. Kleitman. "Cyclic Variations In EEG During Sleep And Their Relation To Eye     Movements, Body Motility, And Dreaming." Electroencephalography and Clinical        Neurophysiology 9.4 (2003): 673-90. ScienceDirect. Web. 14 Jan. 2015.  

4. Iliff, Jeffrey, Minghuan Wang, et al. "A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β." National Center for Biotechnology Information. U.S. National Library of Medicine, 15 Aug. 2012. Web. 14 Jan. 2015.

5.  "The Four Brain States." Tools for Wellness. Web. 14 Jan. 2015.              

6.  Lüthi, A. "Sleep Spindles: Where They Come From, What They Do." National Center for         Biotechnology Information. U.S. National Library of Medicine, 27 Aug. 2013. Web. 14 Jan. 2015.
7. Hobson, J. Allan. "REM Sleep And Dreaming: Towards A Theory Of Protoconsciousness." Nature     Reviews Neuroscience (2009): 803-13. Nature Review Neuroscience. Web. 14 Jan. 2015.

8. Domhoff, G. William. "The Purpose of Dreams." DreamResearch.net. Web. 14 Jan. 2015.

9. Breecher, Maury. "The Biology of Dreaming: A Controversy That Won't Go to Sleep." Columbia University. Web. 14 Jan. 2015.

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